Chromopyrrolic
WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 WebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; …
Chromopyrrolic
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WebMay 1, 2015 · A similar path occurs in the biosynthesis of staurosporine. RebO and RebD can be interchanged with the equivalent StaD and StaP enzymes because chromopyrrolic acid (CPA), 3 or its chlorinated derivative, is common to both paths. Download : Download high-res image (67KB) Download : Download full-size image; Scheme 1. WebJul 1, 2008 · The crystal structure of chromopyrrolic acid-bound P450 StaP, QM/MM calculations, and enzyme assay of several active site mutants suggest that the substrate is tightly bound in the distal pocket...
WebJun 12, 2014 · This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. The structure of chromopyrrolic acid was closely related to that of violacein and deoxyviolacein. The pyrrole dicarboxylic acid moiety of chromopyrrolic … WebApr 5, 2012 · Chromopyrrolic acid-soaked RebC-10x with bound 7-carboxy-K252c. PDB DOI: 10.2210/pdb4EIQ/pdb; Classification: Oxidoreductase/Oxidoreductase inhibitor; …
WebApr 5, 2012 · 4EIP, 4EIQ. PubMed Abstract: The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products … WebJan 3, 2024 · Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food industries. …
Webchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula C22H15N3O4 Net Charge 0 Average Mass 385.373 Monoisotopic Mass 385.10626 InChI
WebJun 6, 2007 · A key step in staurosporine biosynthesis is the formation of the indolocarbazole core by intramolecular C-C bond formation and oxidative decarboxylation of chromopyrrolic acid (CPA) catalyzed by cytochrome P450 StaP (StaP, CYP245A1). In this study, we report x-ray crystal structures of CPA-bound and -free forms of StaP. grand filonChromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid. chinese chive dumpling recipeWebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid. Journal Of The American Chemical Society, 128 (37). 12289-12298 doi:10.1021/ja063898m grand films al pacinoWebJan 1, 2006 · Chromopyrrolic acid is oxidized by six electrons compared to the starting pair of L-tryptophan molecules. RebO is an L-tryptophan oxidase flavoprotein and RebD a … grand filano hybrid connected absWebApr 29, 2024 · What is claimed is: 1. A method of inhibiting or partially inhibiting activity of one or more PIM (proviral integration site for Moloney murine leukemia virus) kinase(s) comprising contacting a PIM kinase with a compound of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate, hydrate, or N-oxide, prodrug, or isotopic … chinese chives cakesWebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45]. chinese chive seedsWebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and … chinese chlorine tablets