Cyclopropane fatty acid synthase
WebOct 30, 2024 · Cyclopropane fatty acids (CPFAs) are an investigated class of secondary fatty acids of microbial origin recently identified in foods. Even though the dietary daily intake of this class of compounds it has been recently estimated as not negligible, to date, no studies specifically have investigated their presence in human plasma after … In enzymology, a cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + phospholipid olefinic fatty acid S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid Thus, the two substrates of this enzyme are S-adenosyl methionine and phospholipid olefinic fatt…
Cyclopropane fatty acid synthase
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WebDec 17, 2002 · The cyclopropane fatty acid synthase gene ( cfa) of Clostridium acetobutylicum ATCC 824 was cloned and overexpressed under the control of the clostridial ptb promoter. The function of the cfa gene was confirmed by complementation of an Escherichia coli cfa -deficient strain in terms of fatty acid composition and growth rate … WebMar 12, 2024 · In this work, we studied in vitro the effect of the thiourea drug isoxyl on six epoxide hydrolases of M. tuberculosis using a fatty acid substrate. We show that one of the proteins inhibited by isoxyl is EphD, an enzyme involved in the metabolism of mycolic acids, key components of the mycobacterial cell wall.
WebMay 5, 2024 · The E. coli fatty acid synthase gene was introduced into several genetic backgrounds of the yeast Y. lipolytica to optimize lipid synthesis; the mean cyclopropane fatty acid productivity was 43 mg L−1 h−1 on glucose, and the production rate reached its maximum (3.06 g L−1) after 72 h of cultivation in a bioreactor. WebThe versatile compound n-butanol is one of the most promising biofuels for use in existing internal combustion engines, contributing to a smooth transition towards a clean energy society. Furthermore, n-butanol is a valuable resource to produce more complex molecules such as bioplastics. Microbial production of n-butanol from waste materials is hampered …
WebMar 4, 2024 · The lipids containing cyclopropane-fatty-acid (CFA) protect bacteria from adverse conditions such as acidity, freeze-drying desiccation and exposure to pollutants. CFA is synthesized when cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase, CFAS) transfers a methylene group from S-adenosylmethionine (SAM) across the … WebMay 1, 2011 · @article{osti_1044002, title = {Characterization and analysis of the cotton cyclopropane fatty acid synthase family and their contribution to cyclopropane fatty acid synthesis}, author = {H, Yu X and Shanklin, J and Rawat, R}, abstractNote = {Cyclopropane fatty acids (CPA) have been found in certain gymnosperms, Malvales, Litchi and other …
WebCai, Y. & Shanklin, J. (2024). Two Clusters of Residues Contribute to the Activity and Substrate Specificity of Fm1, a Bifunctional Oleate and Linoleate Desaturase of Fungal Origin.
WebThe cyclopropane fatty acids have similar biophysical properties to the UFAs, but render the membrane more stable to environmental insults, … dga hypotheekWebApr 1, 2012 · Identification and functional analysis of the cyclopropane fatty acid synthase of Brucella abortus Microbiology Society Volume 158, Issue 4 Research Article Free Identification and functional analysis of the cyclopropane fatty … dgai music schoolWebA large structural diversity of free fatty acids (FFAs) with over 50 different n- and branched-chain, (un)saturated, and cyclopropane FAs (C7–C30) has been demonstrated. There is a strong rationale behind elucidating mechanisms for overproduction of FFA and their export to medium, since it can be exploited in microbial biodiesel production. dga historiaWebSep 1, 2005 · Cyclopropane fatty acid (CFA) synthases catalyze the formation of cyclopropane rings on isolated and unactivated olefinic bonds within various fatty acids; the methylene carbon is... dga hurricaneWebGenetic predictions indicate that the cyclopropane fatty acid (CFA) pathway is present, conferring acid-resistance properties to the cells. The two novel strains might possess a class IV polyhydroxyalcanoate (PHA) synthase operon involved in the P3HB production pathway. Overall, the polyphasic taxonomic analysis shows that these two novel ... dga home servicesdgai maligne hyperthermieWebMay 1, 2002 · Cyclopropane Fatty Acid Synthase from Escherichia coli: Enzyme Purification and Inhibition by Vinylfluorine and Epoxide-Containing Substrate Analogues. ChemBioChem 2003, 4 (12) , 1352-1356. DOI: 10.1002/cbic.200300767. Claudia Knief, Karlheinz Altendorf, Andre Lipski. dgal dartmouth